The N-terminal region of malaria vaccine candidate Plasmodium falciparum asparagine-rich merozoite antigen is immunodominant and targeted by polyreactive antibodies
Rolando Garza, Jeffrey Marchioni, Jared D. Honeycutt, Nicholas K. Hurlburt, Caroline Torres, Anakaren Garcia, Siddharth Neog, Eva Loranc, Emily Yemington, Dalton Towers, Isaac Ssewanyana, Marie Pancera, Jason J. Lavinder, Prasanna Jagannathan, Bryan Greenhouse, , Evelien M. Bunnik
This study investigates B cell and antibody responses to PfARMA, finding that IgM and IgG predominantly target the N-terminal IDR1 region, but these responses do not correlate with protection against malaria.
Disease Models & Mechanisms · May 1, 2026Peer-reviewedImmunology