A Coronaviral Pore-Replicase Complex Drives RNA Synthesis in Double Membrane Vesicles
Anan Chen, Ana‐Mihaela Lupan, Rui Tong Quek, Stefan G. Stanciu, Mihaela Asaftei, George A. Stanciu, Kierra S. Hardy, Taciani de Almeida Magalhães, Pamela A. Silver, Timothy John Mitchison, Adrian N. Salic
This study identifies nsp4 as the key organizer of coronavirus DMV pores and shows it regulates mRNA exit with implications for antiviral strategies.
Science Advances · Nov 8, 2024Peer-reviewedBiochemistry