Author

Rui Tong Quek

Harvard UniversityORCID 0000-0002-0192-8279Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Kierra S. Hardy· 3 shared Pamela A. SilveriD· 3 shared Timothy John MitchisoniD· 3 shared Adrian N. SaliciD· 2 shared Taciani de Almeida MagalhãesiD· 2 shared Ana‐Mihaela LupaniD· 1 shared Anan Chen· 1 shared Christina L. YoungiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersMolecular Biology

Kierra S. Hardy

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3 papers

Recent·Most cited

Molecular BiologySLAS DISCOVERYPeer-reviewedFeb 1, 2025

Comparative evaluation of cell-based assay technologies for scoring drug-induced condensation of SARS-CoV-2 nucleocapsid protein

Rui Tong Quek, Cyna R. Shirazinejad, Christina L. Young…·Pamela A. Silver

The paper evaluates two cell-based assays for detecting drug-induced condensation of SARS-CoV-2 nucleocapsid protein, finding they provide complementary information to traditional high-content screens.

2 citations

protein structureexperimental assay

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BiochemistryScience AdvancesPeer-reviewedNov 8, 2024

A Coronaviral Pore-Replicase Complex Drives RNA Synthesis in Double Membrane Vesicles

Anan Chen, Ana‐Mihaela Lupan, Rui Tong Quek…·Adrian N. Salic

This study identifies nsp4 as the key organizer of coronavirus DMV pores and shows it regulates mRNA exit with implications for antiviral strategies.

20 citationstop 2%

proteomicsexperimental assay

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Molecular BiologyACS Chemical BiologyPeer-reviewedFeb 16, 2023

A screen for modulation of nucleocapsid protein condensation identifies small molecules with anti-coronavirus activity

Rui Tong Quek, Kierra S. Hardy, Stephen G. Walker…·Timothy John Mitchison

The paper identifies small molecules that modulate SARS-CoV-2 nucleocapsid protein condensation and show anti-coronavirus activity across multiple strains.

15 citations

humanexperimental assay

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