Timothy John Mitchison

This study shows that dendritic morphology constrains microtubule dynamics and organization in Drosophila neurons, challenging the traditional view that microtubules shape cell morphology.

This study shows STMN2 stabilizes by binding to tubulin, reducing its membrane localization and degradation, and proposes its neuroprotective role depends on its membrane-bound form.

The paper investigates aggresome formation by reconstituting aggregate transport in Xenopus egg extract, finding that episodic dynein-mediated transport enables positive size selectivity.

The paper evaluates two cell-based assays for detecting drug-induced condensation of SARS-CoV-2 nucleocapsid protein, finding they provide complementary information to traditional high-content screens.

This study shows that three MT-destabilizing drugs induce similar molecular responses in endothelial cells, suggesting clinical differences arise from pharmacokinetics rather than molecular mechanisms.

This study identifies nsp4 as the key organizer of coronavirus DMV pores and shows it regulates mRNA exit with implications for antiviral strategies.

The paper identifies small molecules that modulate SARS-CoV-2 nucleocapsid protein condensation and show anti-coronavirus activity across multiple strains.

The paper investigates the role of Wnt11 family proteins in frog gastrulation, showing that their loss disrupts blastopore closure and endoderm internalization through effects on cell contractility and morphology.

The paper develops a high-content assay to identify viral genes that suppress innate immunity and validates known and novel immune suppressors from various viral families.

The paper screens coronavirus proteins for innate immune suppression, finding SARS-CoV-2 proteins are more potent immune suppressors than other coronaviruses.

The paper investigates how microtubule plus-end density affects growth rates, providing experimental evidence for feedback mechanisms in microtubule dynamics.

The paper uses machine learning to analyze toxicogenomic data and identifies toxin-induced disease states, tolerance mechanisms, and organ-to-whole-body communication in rats.

The paper investigates the role of calcium in STING signaling, finding that calcium mobilization is required for DMXAA-induced signaling but not for cGAMP-induced signaling.