Author

Adrian N. Salic

Harvard UniversityORCID 0000-0002-0748-9545Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Taciani de Almeida MagalhãesiD· 3 shared Kierra S. Hardy· 2 shared Pamela A. SilveriD· 2 shared Rui Tong QuekiD· 2 shared Timothy John MitchisoniD· 2 shared Adina F. TurcuiD· 1 shared Aishwarya Seth· 1 shared Amy E. O’ConnelliD· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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3 shared papersBiochemistry

Taciani de Almeida MagalhãesORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A Coronaviral Pore-Replicase Complex Drives RNA Synthesis in Double Membrane Vesicles

Anan Chen, Ana‐Mihaela Lupan, Rui Tong Quek, Stefan G. Stanciu, Mihaela Asaftei, George A. Stanciu, Kierra S. Hardy, Taciani de Almeida Magalhães, Pamela A. Silver, Timothy John Mitchison, Adrian N. Salic

This study identifies nsp4 as the key organizer of coronavirus DMV pores and shows it regulates mRNA exit with implications for antiviral strategies.

Science Advances · Nov 8, 2024Peer-reviewedBiochemistry

Non-canonical Wnt signaling triggered by WNT2B drives adrenal aldosterone production

Kleiton Silva Borges, Donald W. Little, Taciani de Almeida Magalhães, Claudio Henrique T. Ribeiro, Typhanie Dumontet, Christopher Ryan LaPensee, Kaitlin J. Basham, Aishwarya Seth, Svetlana Azova, Nick A. Guagliardo, Paula Q. Barrett, Mesut Berber, Amy E. O’Connell, Adina F. Turcu, Antônio Marcondes Lerário, , Gary Douglas Hammer

This study identifies WNT2B as a key regulator of adrenal aldosterone production, showing its role in zG function and linking its variants to primary aldosteronism and a new form of familial hypoaldosteronism.

bioRxiv · Aug 23, 2024 · PreprintGenetics

A screen for modulation of nucleocapsid protein condensation identifies small molecules with anti-coronavirus activity

Rui Tong Quek, Kierra S. Hardy, Stephen G. Walker, Dan T. Nguyen, Taciani de Almeida Magalhães, Adrian N. Salic, Sujatha M. Gopalakrishnan, Pamela A. Silver, Timothy John Mitchison

The paper identifies small molecules that modulate SARS-CoV-2 nucleocapsid protein condensation and show anti-coronavirus activity across multiple strains.

ACS Chemical Biology · Feb 16, 2023Peer-reviewedMolecular Biology