Expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD.
Lindsey D. Goodman, Mercedes Prudencio, Nicholas J. Kramer, Luis F. Martinez-Ramirez, Ananth R. Srinivasan, Matthews Lan, Michael J Parisi, Yongqing Zhu, Jeannie Chew, Casey N. Cook, Amit Berson, Aaron D. Gitler, Leonard Petrucelli, Nancy M. Bonini
The paper identifies the PAF1 complex as a mediator of expanded GGGGCC repeat transcription in C9orf72-associated FTD, showing its role in RNA toxicity and disease progression.
Nature Neuroscience · May 20, 2019Peer-reviewedNeuroscience