Lindsey D. Goodman

Revealing the nervous system requirements of Alzheimer disease risk genes in Drosophila

This study identifies nervous system requirements for Alzheimer's disease risk genes in Drosophila by analyzing gene function and neurodegeneration.

Whole organism snRNA-seq reveals systemic peripheral changes in Alzheimer's Disease fly models

The paper uses snRNA-seq in Drosophila to study how AD-associated proteins affect peripheral tissues, finding distinct impacts of Aβ42 and Tau on sensory neurons and non-neuronal tissues.

Drospondin, a novel glial-secreted glycoprotein, controls the development and function of the Drosophila nervous system

This study identifies Drospondin, a Drosophila homolog of mammalian Reelin, showing it is essential for nervous system development and function.

Alzheimer's disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication

The paper identifies an AD protective allele of CLU that enhances neuronal excitability via lipid-droplet-mediated neuron-glia communication.

Neuronal ROS-Induced Glial Lipid Droplet Formation is Altered by Loss of Alzheimers Disease-associated Genes

This study identifies cell-specific roles of AD risk genes in ROS-induced glial lipid droplet formation and shows how their loss affects Aβ42 toxicity and plaque formation.

Expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD.

The paper identifies the PAF1 complex as a mediator of expanded GGGGCC repeat transcription in C9orf72-associated FTD, showing its role in RNA toxicity and disease progression.