Nancy M. Bonini

This study shows that peripheral metabolic dysfunction, not just neuronal loss, causes sleep disruption in TDP-43 proteinopathy by identifying SIK3 as a key regulator.

This study shows that increasing ACSS2 levels protects neurons from age-related and tau-induced decline by enhancing synaptic and longevity gene expression.

The paper investigates chromatin conformation changes in Alzheimer's disease, finding loss of genomic loops and CTCF dysfunction linked to neurodegeneration.

This study shows ACSS2-mediated histone acetylation is critical for learning and memory in a mouse AD model, with acetate supplementation rescuing deficits.

This study identifies glial AP1 as a dual-factor promoting early TBI recovery but driving chronic tauopathy, with similar activation observed in aging brains.

This study investigates the role of parkin in maintaining gut microbiota in Drosophila parkinsonism models, finding that parkin loss increases bacterial load and that germ-free conditions improve paraquat resistance.

The paper identifies the PAF1 complex as a mediator of expanded GGGGCC repeat transcription in C9orf72-associated FTD, showing its role in RNA toxicity and disease progression.