Conditional fusogenic lipid nanocarriers for cytosolic delivery of macromolecular therapeutics
Qian Zhong, Edward K.W. Tan, Ananth Shyamal, Chayanon Ngambenjawong, Tiziana Parisi, Henry Ko, Heather E. Fleming, Tyler Jacks, Sangeeta N. Bhatia
This paper develops C-FLIPs, protease-activated liposomes that deliver macromolecular therapeutics to the cytosol of cancer cells, inducing tumor regression and immune memory.
bioRxiv · Dec 27, 2024 · PreprintBioengineering