Heather E. Fleming

Decoding & manipulating human intercellular signaling via scalable cell-free protein synthesis

The paper develops scalable cell-free protein synthesis platforms to generate single-cell RNA-sequencing data on immune cell responses to cytokines and other signals, enabling functional discovery and drug target prioritization.

Image-Guided Injectable Niche for Hepatocyte Transplantation

The paper develops INSITE, an injectable platform for hepatocyte transplantation that enables precise delivery and long-term function through image-guided assembly into vascularizable scaffolds.

Expanding antimicrobial chemical space by engineering drug safety

This paper introduces a dual strategy to improve antimicrobial safety by engineering conditionally-active drug conjugates and co-administering antidotes, reducing toxicity while maintaining efficacy against bacterial infections.

Engineering Multiplexed Synthetic Breath Biomarkers as Diagnostic Probes

This paper engineers multiplexed synthetic breath biomarkers to detect disease-specific protease activities and applies them to diagnose lung cancer and monitor treatment response in mice.

Conditional fusogenic lipid nanocarriers for cytosolic delivery of macromolecular therapeutics

This paper develops C-FLIPs, protease-activated liposomes that deliver macromolecular therapeutics to the cytosol of cancer cells, inducing tumor regression and immune memory.