Comprehensive preclinical evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of C9ORF72 disease
Mélanie Jambeau, Kevin D. Meyer, Marián Hruška-Plocháň, Ricardos Tabet, Chao-Zong Lee, Ananya Ray-Soni, Corey Aguilar, Kitty Savage, Nibha Mishra, Nicole Cavegn, Petra Borter, Chun-Chia Lin, Karen R. Jansen‐West, Jie Jiang, Fernande Freyermuth, , Clotilde Lagier‐Tourenne
This study evaluates human-derived anti-poly-GA antibodies in cellular and animal models of C9ORF72 disease, showing mixed effects on poly-GA levels and disease progression.
Proceedings of the National Academy of Sciences · Dec 1, 2022Peer-reviewedNeuroscience