Christoph Höck

The paper identifies T-cell co-signalling states linked to vulnerability and resilience to cerebral Aβ pathology in Alzheimer's disease.

This paper maps α-synuclein pathology and dopaminergic degeneration in mice using multimodal imaging and microscopy, showing spread along the nigrostriatal pathway and microstructural changes.

The paper examines immune changes in early Alzheimer's disease stages, finding altered T cell reactivity to β-amyloid-related antigens in preclinical AD and MCI.

The paper examines reduced SV2A levels in AD brain tissue and extracellular vesicles, linking them to amyloid-β, tau, and synaptic markers.

This study finds no difference in hippocampal mGluR5 levels between Alzheimer's and control brains, but shows amyloid and tau have opposing effects on mGluR5 in controls.

The paper uses multimodal imaging to assess spinal cord oxygenation and vascular changes in a PD mouse model, finding reduced oxygen saturation but no vascular impairment or atrophy.

The paper examines increased P2X7R levels in Alzheimer's disease hippocampi, correlating with amyloid and tau pathologies, and identifies its potential as a neuroinflammation marker.

The paper develops an automatic pipeline for analyzing skull thickness and scalp-to-cortex distance from MRI data and shows age and sex-related changes in these metrics in elderly individuals.

This paper demonstrates noninvasive transcranial MSOT angiography in a human volunteer and validates its anatomical alignment with MRI.

This study evaluates human-derived anti-poly-GA antibodies in cellular and animal models of C9ORF72 disease, showing mixed effects on poly-GA levels and disease progression.