Pleiotropic effects of trisomy and pharmacologic modulation on structural, functional, molecular, and genetic systems in a Down syndrome mouse model
Sergi Llambrich, Birger Tielemans, Ellen Saliën, Marta Atzori, Kaat Wouters, Vicky Van Bulck, Mark Platt, Laure Vanherp, Nuria Gallego Fernandez, Laura Grau de la Fuente, Harish Poptani, Lieve Verlinden, Uwe Himmelreich, Anca Croitor, Catia Attanasio, , Greetje Vande Velde
This study evaluates the effects of trisomy and GTE-EGCG treatment on multiple systems in a Down syndrome mouse model, finding that treatment exacerbates trisomic phenotypes rather than rescuing them.
eLife · Oct 6, 2023Peer-reviewedSystems Biology