Transgenic dCas9-DNMT3A mouse lines enable ex vivo and in vivo methylation editing with locus-dependent transcriptional effects
Maria Kalomoiri, Chiara Sorini, Sebastiaan Volkert Timotheus Vos, Anderson Camargo, Alesia Tsalikou, Aleksa Krstic, Chandana Rao Prakash, Per Svenningsson, Maria Needhamsen, Majid Pahlevan Kakhki, Lara Kular, Maja Jagodic
This study develops CRISPR-based mouse lines for locus-specific DNA methylation editing and shows locus-dependent transcriptional effects in vivo.
bioRxiv · Jun 30, 2026 · PreprintMolecular Biology