Author

Chiara Sorini

Karolinska University HospitalORCID 0000-0002-6803-8377Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:clustering· 1

Frequent Co-Authors

Majid Pahlevan KakhkiiD· 3 shared Maria NeedhamseniD· 3 shared Aleksa KrsticiD· 2 shared Chandana Rao Prakash· 2 shared Fredrik PiehliD· 2 shared Lara KulariD· 2 shared M Jagodic· 2 shared Mohsen KhademiiD· 2 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Majid Pahlevan KakhkiORCID

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3 papers

Recent·Most cited

Transgenic dCas9-DNMT3A mouse lines enable ex vivo and in vivo methylation editing with locus-dependent transcriptional effects

Maria Kalomoiri, Chiara Sorini, Sebastiaan Volkert Timotheus Vos, Anderson Camargo, Alesia Tsalikou, Aleksa Krstic, Chandana Rao Prakash, Per Svenningsson, Maria Needhamsen, Majid Pahlevan Kakhki, Lara Kular, Maja Jagodic

This study develops CRISPR-based mouse lines for locus-specific DNA methylation editing and shows locus-dependent transcriptional effects in vivo.

bioRxiv · Jun 30, 2026 · PreprintMolecular Biology

Epigenomic profiling of cerebrospinal fluid cells identifies immune regulatory alterations and implicates protocadherins in multiple sclerosis

Yanan Han, Galina Yurevna Zheleznyakova, Chiara Sorini, Majid Pahlevan Kakhki, Nicolas Ruffin, Heng Liang, Nils Hallen, Chandana Rao Prakash, Viveca Beckers, Elena Ivanova, Mohsen Khademi, Mikael C. I. Karlsson, Fredrik Piehl, Tomas P Olsson, Gavin Kelsey, , M Jagodic

This study identifies DNA methylation changes in cerebrospinal fluid cells from MS patients, linking them to immune regulatory alterations and implicating protocadherins in MS pathogenesis.

bioRxiv · Feb 27, 2026 · PreprintImmunology

Anoctamin-2-specific T Cells Link Epstein-Barr Virus to Multiple Sclerosis

Olivia G. Thomas, Urszula Rykaczewska, Marina Galesic, Rianne T. M. van der Burgt, Nils Hallen, Filippo Ferro, Mattias Bronge, Zoe Marti, Yue Li, Alexandra Hill Rique, Jianing Lin, Aleksa Krstic, Alicja Gromadzka, Andras Levente Szonder, Chiara Sorini, , Tomas P Olsson

CD4+ T cells cross-reactive between Epstein-Barr virus EBNA1 and the central nervous system channel anoctamin-2 (ANO2) are elevated in multiple sclerosis and exacerbate experimental autoimmune encephalomyelitis in mice.

Cell · Jan 1, 2026Peer-reviewedImmunology✦ In-depth digest