Antigen recognition licenses therapeutic CD8+ T cells to organize a multicellular myeloid interaction network in the tumor microenvironment
Alfredo Pherez-Farah, Willem de Koning, Weisha Qi, Gioia Boncompagni, Enrico Dotta, Edoardo Peroni, Tania Baccega, Agnieszka Katarzyna Macioła, Giuseppe Rocca, Greta Maria Paola Giordano Attianese, Francesca Granucci, Melita B. Irving, Andew Stubbs, Giulia Pasqual
This study investigates how therapeutic CD8+ T cells interact with myeloid cells in the tumor microenvironment through antigen recognition, revealing state-selective networks and the role of pMHC-I sources.
bioRxiv · Oct 20, 2026 · PreprintImmunology