Francesca Granucci

The paper shows that distinct dendritic cell subsets sequentially engage CD4 T cells during priming, with late CD70 DC2s driving Th2 polarization.

This study investigates how therapeutic CD8+ T cells interact with myeloid cells in the tumor microenvironment through antigen recognition, revealing state-selective networks and the role of pMHC-I sources.

The paper reveals a two-tier mechanism of neutrophil recruitment during infections, where mechanosensing initiates innate immunity through PIEZO1 channels and LTB4 production.