Polygenic scores for major depressive disorder and depressive symptoms predict response to lithium in patients with bipolar disorder
Azmeraw T. Amare, Klaus Oliver Schubert, Liping Hou, Scott Richard Clark, Sergi Papiol, Micah Cearns, Urs Heilbronner, Franziska Degenhardt, Fasil Tekola Ayele, Yi‐Hsiang Hsu, Tatyana Shekhtman, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, , Mario Maj
The paper shows that polygenic scores for depression traits predict lithium response in bipolar disorder patients, with lower genetic load linked to better treatment outcomes.
bioRxiv · Oct 26, 2018 · PreprintGenomics