Alessio Squassina

The paper measures SLC6A6 mRNA expression in lymphoblastoid cell lines from Alzheimer's disease patients and finds it is 2.8-fold lower than in age-matched controls, suggesting a potential role for taurine in AD pathogenesis.

This study performs APOE-stratified GWAS to uncover genetic mechanisms underlying Alzheimer's disease risk and response to therapies.

This paper identifies genetic signatures in lymphoblastoid cell lines associated with suicide risk in bipolar disorder patients using RNA sequencing and machine learning.

The paper shows that polygenic scores for depression traits predict lithium response in bipolar disorder patients, with lower genetic load linked to better treatment outcomes.

This study performs a large GWAS of Alzheimer's disease, identifies four new risk loci, and highlights pathways involving immunity, lipid metabolism, and APP/Aβ processing.

This study finds that a higher genetic risk for schizophrenia is linked to poorer lithium response in bipolar disorder patients, suggesting potential for personalized treatment strategies.