Purinergic signaling promotes gliomagenesis through nuclear calcium transients
Shuai Wang, Jenna Richter, Claire Kim, Rebecca Ronnen, Julia Cai, Yunfei Song, Sara Haddock, Mark B. Stoessel, Hannah Dada, Suzanne Gross, Adler Guerrero, Theodoris Karnavas, Gabriele Stephan, Greg Belizaire, Luke J. Bonanni, , Dimitris G. Placantonakis
This study identifies purinergic signaling via P2RY1 receptors and nuclear calcium transients as a driver of glioblastoma tumorigenesis, with therapeutic potential through P2RY1 inhibition.
bioRxiv · May 15, 2026 · PreprintCancer Biology