Andrea H. Brand

Sex Steroid Hormone Signaling Tunes Metabolic and Neuronal Programs in Human Cortical Development

The paper investigates how sex steroid hormones influence metabolic and neuronal programs during human cortical development using single-cell RNA-seq and hormone exposure experiments.

Purinergic signaling promotes gliomagenesis through nuclear calcium transients

This study identifies purinergic signaling via P2RY1 receptors and nuclear calcium transients as a driver of glioblastoma tumorigenesis, with therapeutic potential through P2RY1 inhibition.

Quiescent neural stem cells transiently become 'neurons' to coordinate reactivation

The paper shows quiescent neural stem cells temporarily express neuronal genes to coordinate reactivation during CNS development.

Neural stem cell quiescence is actively maintained by the epigenome

The paper maps epigenomic changes in Drosophila neural stem cells during quiescence and reactivation, finding increased chromatin accessibility without transcriptional activation.

A conserved differentiation program facilitates inhibitory neuron production in the developing mouse and human cerebellum

The paper identifies FOXO1 as a key regulator of inhibitory neuron differentiation in mouse and human cerebellar progenitors, showing its conservation and regulation by WNT signaling.

Targeting the acetyltransferase NAT10 corrects pathologies in human frontotemporal dementia neurons and extends lifespan in an in vivo Drosophila tauopathy model

The paper shows that inhibiting NAT10 corrects nuclear defects and extends lifespan in tauopathy models.

Targeted DamID detects cell-type specific histone modifications in vivo

The paper introduces Targeted DamID to detect cell-type specific histone modifications in vivo across different model organisms.

An organoid CRISPRi screen revealed that SOX9 primes human fetal lung tip progenitors to receive WNT and RTK signals

The paper uses a CRISPRi screen in human fetal lung organoids to identify SOX9 as a key regulator of progenitor self-renewal, showing it primes cells to receive WNT and RTK signals.

NanoDam identifies novel temporal transcription factors conserved between the Drosophila central brain and visual system

The paper introduces NanoDam, a method to identify temporal transcription factors in Drosophila, finding Homeobrain and Scarecrow as conserved factors in both central brain and visual system development.

Novel CHD8 genomic targets identified in fetal mouse brain by in vivo Targeted DamID

This study identifies novel CHD8 genomic targets in fetal mouse brain using in vivo Targeted DamID, revealing binding sites related to neurodevelopment and autism-relevant biology.