The paper identifies a developmentally regulated long-range enhancer-promoter contact that is critical for SOX2 expression and neuroectodermal differentiation in human neural development.

bioRxiv · Sep 11, 2026 · PreprintDevelopmental Biology

Purinergic signaling promotes gliomagenesis through nuclear calcium transients

Shuai Wang, Jenna Richter, Claire Kim, Rebecca Ronnen, Julia Cai, Yunfei Song, Sara Haddock, Mark B. Stoessel, Hannah Dada, Suzanne Gross, Adler Guerrero, Theodoris Karnavas, Gabriele Stephan, Greg Belizaire, Luke J. Bonanni, , Dimitris G. Placantonakis

This study identifies purinergic signaling via P2RY1 receptors and nuclear calcium transients as a driver of glioblastoma tumorigenesis, with therapeutic potential through P2RY1 inhibition.

bioRxiv · May 15, 2026 · PreprintCancer Biology

YTHDF1 mediates translational control by m6A mRNA methylation in adaptation to environmental challenges

Zhuoyue Shi, Kailong Wen, Wenqin Fu, Zhongyu Zou, Kathryn Guo, Nabilah H. Sammudin, Meera J. Patel, Xiangbin Ruan, Shivang Sullere, Shuai Wang, Xiaochang Zhang, Gopal Thinakaran, Chuan He, Xiaoxi Zhuang

This study shows that YTHDF1 mediates m6A mRNA methylation in neuronal adaptation to environmental challenges, with distinct roles in D1 and D2 neurons.

Proceedings of the National Academy of Sciences · Apr 13, 2026Peer-reviewedNeuroscience

Proteomic characterization of the Alzheimer's disease risk factor BIN1 interactome

Joseph D. McMillan, Shuai Wang, Jessica Wohlfahrt, Jennifer Guergues, Stanley M. Stevens, Gopal Thinakaran

This study identifies BIN1-interacting proteins in neurons using TurboID-based proximity labeling, revealing 361 and 897 proteins in cultured cells and brain neurons, respectively.

Molecular & Cellular Proteomics · Aug 19, 2025Peer-reviewedNeuroscience