SNAP25 disease mutations change the energy landscape for synaptic exocytosis due to aberrant SNARE interactions
Anna Kádková, Jacqueline Murach, Maiken Østergaard, Andrea Malsam, Jörg Malsam, Fabio Lolicato, Walter Nickel, Thomas H. Söllner, Jakob Balslev Sørensen
This study examines how disease mutations in SNAP25 alter the energy landscape of synaptic exocytosis by affecting SNARE interactions and fusion dynamics in neurons.
eLife · Jul 12, 2023Peer-reviewedNeuroscience