Jakob Balslev Sørensen

The paper introduces CryoVesNet, a framework for automated synaptic vesicle segmentation in cryo-ET data, improving accuracy and efficiency compared to manual methods.

This study identifies excitatory synapse dysfunction in microcircuits as the cause of hyperexcitability in Stxbp1 haploinsufficiency and shows that ampa-kines can rescue this defect.

This study examines how disease mutations in SNAP25 alter the energy landscape of synaptic exocytosis by affecting SNARE interactions and fusion dynamics in neurons.

The paper uses cryo-electron tomography to sequence events during synaptic vesicle exocytosis and identifies how tether formation and connector dissolution are regulated by stimulation and spontaneous fusion rate.

The paper investigates the opposing roles of Munc13-1 and ubMunc13-2 in dense-core vesicle secretion in response to phorbolesters, showing that ubMunc13-2 promotes secretion while Munc13-1 inhibits it, with syt7 mediating the stimulatory effect of phorbolesters.

The paper models how synaptotagmins' dual Ca2+/PI(4,5)P2 binding stabilizes exocytosis by lowering the energy barrier for vesicle fusion.

This study investigates the roles of synaptotagmin-1 and synaptotagmin-7 in Ca2+-dependent vesicle priming and exocytosis in mouse chromaffin cells, showing their synergistic effects.

This study shows endophilin-A1 and A2 regulate exocytosis of neurosecretory vesicles by controlling recruitment, priming, and fusion, independent of their endocytic roles.