Author

Jörg Malsam

Heidelberg University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:electronic health records· 2 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

Thomas H. SöllneriD· 3 shared Christian RosenmundiD· 2 shared Jacqueline Murach· 2 shared Simon Bärfuss· 2 shared Thorsten TrimbuchiD· 2 shared Andrea Malsam· 1 shared Andrea Scheutzow· 1 shared Andreas F.‐P. SonneniD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersNeuroscience

Thomas H. SöllnerORCID

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Author profile →

3 papers

Recent·Most cited

Single residues in the complexin N-terminus exhibit distinct phenotypes in synaptic vesicle fusion

Estelle Toulmé, Jacqueline Murach, Simon Bärfuss, Jana Kroll, Jörg Malsam, Thorsten Trimbuch, Melissa A. Herman, Thomas H. Söllner, Christian Rosenmund

The paper identifies specific amino acid residues in the complexin N-terminus that differentially affect spontaneous and evoked neurotransmitter release in hippocampal neurons.

bioRxiv · Jan 12, 2024 · PreprintNeuroscience

SNAP25 disease mutations change the energy landscape for synaptic exocytosis due to aberrant SNARE interactions

Anna Kádková, Jacqueline Murach, Maiken Østergaard, Andrea Malsam, Jörg Malsam, Fabio Lolicato, Walter Nickel, Thomas H. Söllner, Jakob Balslev Sørensen

This study examines how disease mutations in SNAP25 alter the energy landscape of synaptic exocytosis by affecting SNARE interactions and fusion dynamics in neurons.

eLife · Jul 12, 2023Peer-reviewedNeuroscience

Complexin suppresses spontaneous exocytosis by capturing the membrane-proximal regions of VAMP2 and SNAP25

Jörg Malsam, Simon Bärfuss, Thorsten Trimbuch, Fereshteh Zarebidaki, Andreas F.‐P. Sonnen, Klemens Wild, Andrea Scheutzow, Lukas Rohland, Matthias P. Mayer, Irmgard Sinning, John A. G. Briggs, Christian Rosenmund, Thomas H. Söllner

This study identifies how complexin suppresses spontaneous exocytosis by binding the membrane-proximal regions of VAMP2 and SNAP25.

Cell Reports · Jul 1, 2020Peer-reviewedNeuroscience