This study shows that PI(4,5)P2 transbilayer asymmetry facilitates FGF2 unconventional secretion by enabling membrane pore formation and GPC1-mediated translocation.

Nature Communications · Nov 29, 2025Peer-reviewedBiochemistry

Nanoscale PI(4,5)P2 partitioning driven by FGF2 oligomerization triggers membrane pore formation

Alessandra Griffo, Daniel Beyer, Jaime Fernandez-Sobaberas, Melanie König, Zeynep Kilcan, Manpreet Kaur, Eleonora Germana Margheritis, Katia Cosentino, Petra Riegerová, Martin Hof, Radek Šachl, Walter Nickel, Fabio Lolicato

This paper shows FGF2 oligomerization drives PI(4,5)P2 partitioning and membrane pore formation, enabling FGF2 translocation across the plasma membrane.

bioRxiv · Sep 11, 2025 · PreprintBiochemistry

SNAP25 disease mutations change the energy landscape for synaptic exocytosis due to aberrant SNARE interactions

Anna Kádková, Jacqueline Murach, Maiken Østergaard, Andrea Malsam, Jörg Malsam, Fabio Lolicato, Walter Nickel, Thomas H. Söllner, Jakob Balslev Sørensen

This study examines how disease mutations in SNAP25 alter the energy landscape of synaptic exocytosis by affecting SNARE interactions and fusion dynamics in neurons.

eLife · Jul 12, 2023Peer-reviewedNeuroscience

IFITM3 blocks influenza virus entry by sorting lipids and stabilizing hemifusion

Steffen Klein, Gonen Golani, Fabio Lolicato, Carmen Maria Lahr, Daniel Beyer, Alexia Herrmann, Moritz Wachsmuth-Melm, Nina Reddmann, Romy Brecht, Mehdi Hosseinzadeh, Androniki Kolovou, Jana Makroczyová, Sarah Peterl, Martin Schorb, Yannick Schwab, , Petr Chlanda

This study identifies how IFITM3 inhibits influenza virus entry by stabilizing hemifusion through lipid sorting in endosomal membranes.

Cell Host & Microbe · Mar 31, 2023Peer-reviewedMolecular Biology