VTA dopamine neurons are hyperexcitable in 3xTg-AD mice due to casein kinase 2-dependent SK channel dysfunction
Harris E. Blankenship, Kelsey A Carter, Kevin D. Pham, Nina T. Cassidy, Andrea N. Markiewicz, Michael I. Thellmann, Amanda Lea Sharpe, Willard M. Freeman, Michael J. Beckstead
This study identifies hyperexcitability in VTA dopamine neurons of 3xTg-AD mice due to CK2-dependent SK channel dysfunction, linking it to reward-based learning deficits.
Nature Communications · Nov 8, 2024Peer-reviewedNeuroscience