The unfolded protein response turns from pro-survival to pro-death to cap the extent of endoplasmic reticulum expansion
Milena Vitale, Andrea Orsi, Anush Bakunts, Federica Lari, Laura Tadè, Angela Cattaneo, Roberto Sitia, Andrea Raimondi, Angela Bachi, Eelco van Anken
The paper shows the UPR transitions from pro-survival to pro-death when ER expansion is excessive, using HeLa cells and genetic manipulations.
bioRxiv · May 5, 2017 · PreprintCell Biology