Angela Bachi

This study shows compressive stress activates a calcium-dependent pathway that reduces translation and proteostasis through multiple mechanisms, correlating with poor survival in pancreatic cancer.

The paper identifies the proline-rich domain (PRD) of HTT exon 1 as a modifier of neuronal toxicity in Huntington's disease, showing that the human PRD exacerbates while the mouse PRD mitigates toxicity.

This study shows that NUMB's Ex3 exon directs it to the plasma membrane, forming a complex with SNX9 that recruits and transports p53 via exosomes, enabling p53-dependent transcriptional activity in recipient cells.

This study uses proteomics to analyze astrocyte secretome changes in response to soluble Aβ oligomers, identifying dysregulated proteins and potential biomarkers for Alzheimer's disease.

This study uses patient-specific iPSCs to model GLD, revealing cell type-specific disease phenotypes and the importance of GALC restoration for neural differentiation.

This study identifies IRSp53's role in shaping the plasma membrane and controlling polarized transport during epithelial morphogenesis by regulating apical lumen formation and polarity determinants.

The paper shows the UPR transitions from pro-survival to pro-death when ER expansion is excessive, using HeLa cells and genetic manipulations.