Andrea Raimondi

A reversible temperature block captures pre-lysosomal intermediates of starvation-induced ERphagy

This study identifies a reversible temperature block that captures pre-lysosomal intermediates of ERphagy, showing their formation requires autophagy machinery and reveals their structural features.

Decoding EGFR ligand bias through an endocytic organelle platform

The paper identifies a RAC1-PLCγ2 axis that decodes EGFR ligand bias by linking receptor trafficking to metabolic programs supporting cell migration.

Epstein Barr virus exploits ER stress and TMX4 dependent nuclear envelope remodeling to enable capsid egress

This study shows EBV uses ER stress and TMX4 to remodel the nuclear envelope, enabling capsid egress during viral maturation.

The perineurium integrates leptin with its sympathetic outflow to protect against obesity

This study identifies perineurial cells as integrators of leptin and sympathetic outflow, showing their role in obesity protection through barrier function and beta 2 adrenergic receptor regulation.

IL-16 production is a mechanism of resistance to BTK inhibitors and R-CHOP in lymphomas

This study identifies IL-16 production as a mechanism of resistance to BTK inhibitors and R-CHOP in lymphomas, showing that targeting the IL-16/CD9 axis restores drug sensitivity.

Circulating extracellular vesicles drive microglial senescence and neurodegeneration in Parkinson`s disease

This study shows that circulating extracellular vesicles from Parkinson's disease patients induce microglial senescence and neurodegeneration by promoting inflammation and neuronal damage.

Targeting GL-Lect driven endocytosis to suppress cell plasticity in breast cancer

This study identifies GL-Lect driven endocytosis as a driver of metastatic plasticity in breast cancer and shows pharmacologic inhibition can suppress invasive phenotypes.

ER-phagy and mitophagy programs in human CD4+ memory T cells before and after activation

This study shows that human CD4+ memory T cells use ER-phagy and mitophagy to regulate ER and mitochondrial mass during activation and contraction phases.

Tattoo ink induces inflammation in the draining lymph node and impairs the immune response against a COVID-19 vaccine

This study shows tattoo ink causes long-term inflammation in lymph nodes and reduces vaccine efficacy against COVID-19.

ER-phagy Receptors Intrinsically Disordered Modules Drive ER Fragmentation and ER-phagy

This study shows that intrinsically disordered regions (IDRs) of ER-phagy receptors drive ER fragmentation, not their membrane-remodeling domains.