Follicular helper- and peripheral helper-like T cells drive autoimmune disease in human immune system mice
Mohsen Khosravi-Maharlooei, Andrea Vecchione, Nichole M. Danzl, Hao Wei Li, Grace Nauman, Rachel Madley, Elizabeth Waffarn, ROBERT J. WINCHESTER, Amanda Ruiz, Xiaolan Ding, Georgia Fousteri, Megan Sykes
The paper shows that PD-1+CD4+ Tfh-like and Tph-like cells in human immune system mice drive autoimmune disease, with disease progression linked to HLA-restricted T cell-APC interactions.
bioRxiv · May 2, 2024Immunology