Mohsen Khosravi Maharlooei

This paper develops a human immune system mouse model to study SARS-CoV-2 dissemination and immune responses, finding that human T cells suppress innate immunity and allow viral persistence.

This paper presents a CRISPR-based platform that removes endogenous TCRα/β chains to enhance transgenic TCR function and safety in T-cell therapies and autoimmune modeling.

The paper shows that PD-1+CD4+ Tfh-like and Tph-like cells in human immune system mice drive autoimmune disease, with disease progression linked to HLA-restricted T cell-APC interactions.