Megan Sykes

Coordinated circulating and tissue-based T cell responses precede xenograft rejection

This study tracks T cell clonotypes across tissues in a pig-to-human kidney xenotransplantation model, showing coordinated immune responses preceding xenograft rejection.

A Donor T-Cell Receptor Structural Signature Determines Alloreactive Potential and Predicts Acute Graft-Versus-Host Disease

The paper identifies a T-cell receptor structural signature that predicts acute GVHD risk by analyzing alloreactive clonotypes and introduces a metric to quantify clonal dominance.

A novel model demonstrating that human immune cells promote multiorgan SARS-CoV-2 dissemination and human T cells limit anti-viral innate immunity

This paper develops a human immune system mouse model to study SARS-CoV-2 dissemination and immune responses, finding that human T cells suppress innate immunity and allow viral persistence.

A universal platform for simultaneous TCRα/β removal enables safer and more potent TCR therapies and autoimmune modeling

This paper presents a CRISPR-based platform that removes endogenous TCRα/β chains to enhance transgenic TCR function and safety in T-cell therapies and autoimmune modeling.

Spatiotemporal Single-Cell Analysis Reveals T Cell Clonal Dynamics and Phenotypic Plasticity in Human Graft-versus-Host Disease

This study uses spatiotemporal single-cell analysis to track T cell clonal dynamics and phenotypic plasticity in GVHD, revealing links between TCR features, clonal expansion, and disease severity.

Follicular helper- and peripheral helper-like T cells drive autoimmune disease in human immune system mice

The paper shows that PD-1+CD4+ Tfh-like and Tph-like cells in human immune system mice drive autoimmune disease, with disease progression linked to HLA-restricted T cell-APC interactions.