Genetically-encoded discovery and development of peptide-macrocycle imaging agents for PD-L1
Ratmir Derda, Vincent Albert, Matthew L. Michnik, Hongchang Bao, Tara Bahadur K. C., William Kirby, Haley Irwin, Kristen Maiorana, James C. Walker, Govinda Sharma, Rima Mistry, Abdelrhman Zakaria, Danial Yazdan, Jiahui Wang, Martin Truksa, , Frank R. Wuest
This paper develops PD-L1-targeting macrocycle imaging agents using phage-display technology without non-canonical amino acids, achieving single-digit-nanomolar potency and structural characterization.
bioRxiv · Sep 20, 2026 · PreprintPharmacology & Toxicology