Author

James C. Walker

University of AlbertaORCID 0009-0008-7209-8744Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 1

Frequent Co-Authors

Ratmir DerdaiD· 2 shared Abdelrhman Zakaria· 1 shared Alexey M. Atrazhev· 1 shared Andreas Dorian· 1 shared Arunika I. EkanayakeiD· 1 shared Brett M. BabiniD· 1 shared Cody BergmaniD· 1 shared Danial YazdaniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

Ratmir DerdaORCID

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2 papers

Recent·Most cited

BiochemistryJournal of the American Chemical SocietyPeer-reviewedSep 26, 2026

A Two-Step Synthesis of Covalent Genetically-Encoded Libraries of Peptide-Derived Macrocycles (cGELs) enables use of electrophiles with diverse reactivity

James C. Walker, Arunika I. Ekanayake, Nichole J. Pedowitz…·Ratmir Derda

This paper develops a two-step synthesis method for covalent genetically-encoded libraries of peptide-derived macrocycles (cGELs) that enables the use of electrophiles with diverse reactivity by controlling reaction conditions.

DOI 10.1021/jacs.6c12299

proteomicsexperimental assay

𝕏 PostBluesky

Pharmacology & ToxicologybioRxivPreprintSep 20, 2026

Genetically-encoded discovery and development of peptide-macrocycle imaging agents for PD-L1

Ratmir Derda, Vincent Albert, Matthew L. Michnik…·Frank R. Wuest

This paper develops PD-L1-targeting macrocycle imaging agents using phage-display technology without non-canonical amino acids, achieving single-digit-nanomolar potency and structural characterization.

DOI 10.64898/2026.09.11.750985

experimental assaydrug response / drug discovery

𝕏 PostBluesky