Author

Frank R. Wuest

University of AlbertaORCID 0000-0002-6705-6450Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

Melinda WuestiD· 2 shared Abdelrhman Zakaria· 1 shared Amirali B. BukhariiD· 1 shared Andreas Dorian· 1 shared Armin M. GamperiD· 1 shared Cody BergmaniD· 1 shared Danial YazdaniD· 1 shared Govinda SharmaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersPharmacology & Toxicology

Melinda WuestORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Genetically-encoded discovery and development of peptide-macrocycle imaging agents for PD-L1

Ratmir Derda, Vincent Albert, Matthew L. Michnik, Hongchang Bao, Tara Bahadur K. C., William Kirby, Haley Irwin, Kristen Maiorana, James C. Walker, Govinda Sharma, Rima Mistry, Abdelrhman Zakaria, Danial Yazdan, Jiahui Wang, Martin Truksa, , Frank R. Wuest

This paper develops PD-L1-targeting macrocycle imaging agents using phage-display technology without non-canonical amino acids, achieving single-digit-nanomolar potency and structural characterization.

bioRxiv · Sep 20, 2026 · PreprintPharmacology & Toxicology

FLT-PET as predictive non-invasive biomarker for neoadjuvant therapy with Wee1 and ATR inhibitors

Amirali B. Bukhari, Melinda Wuest, Frank R. Wuest, Armin M. Gamper

This study uses FLT-PET to predict response to DDR inhibitors in breast cancer models, finding early sequential PET can predict efficacy while initial uptake cannot.

bioRxiv · Mar 13, 2026 · PreprintCancer Biology