Expression of human CEACAMs promotes inflammation and organ damage during systemic Candida albicans infection in mice
Esther Klaile, Mario M. Müller, Johannes Sonnberger, Anne-Katrin Bothe, Saskia Brehme, Juliet Ehrenpfordt, Tilman E. Klassert, Sabina Kuhn, Kristina Dietert, Olivia Kershaw, Jan‐Philipp Praetorius, Marc Thilo Figge, Torsten Thomas Bauer, Andreas Gebhardt, Gita Mall, , Hortense Slevogt
This study shows that human CEACAM receptors in mice worsen inflammation and organ damage during Candida albicans infection, leading to shorter survival.
bioRxiv · Mar 29, 2025 · PreprintImmunology