Marc Thilo Figge

J-AST: a web-based analysis platform for antimicrobial susceptibility testing

J-AST is a web-based platform for analyzing antimicrobial susceptibility tests, providing automated annotation and MIC detection with high agreement with manual methods.

Deploying cross-species bone marrow niches to elucidate human hematopoietic stem cell regulation in vivo

This study uses a cross-species bone marrow niche model to show that plasticity in the murine niche supports human HSC engraftment, highlighting its role in stem cell function.

The murine lung microbiome is dynamic and transient

This study shows the murine lung microbiome is dynamic and transient, with bacteria rapidly cleared by the immune system and not establishing stable colonization.

Overcoming Protein A-driven Nonspecific Antibody Staining of S. aureus in Immunofluorescence Microscopy

The paper evaluates methods to reduce nonspecific antibody staining caused by Staphylococcus aureus protein A in immunofluorescence microscopy, finding human serum treatment most effective.

Environmental cues shape extracellular vesicles biogenesis and function in Streptococcus pneumoniae

This study shows environmental factors like temperature, pH, and glucose availability influence extracellular vesicle (EV) production and function in Streptococcus pneumoniae, affecting biofilm formation and interspecies interactions.

Expression of human CEACAMs promotes inflammation and organ damage during systemic Candida albicans infection in mice

This study shows that human CEACAM receptors in mice worsen inflammation and organ damage during Candida albicans infection, leading to shorter survival.

Convergent evolution of a fungal effector enabling phagosome membrane penetration

The paper identifies a single amino acid change in fungal proteins that enables phagosomal membrane penetration, suggesting convergent evolution of virulence mechanisms across fungi.

Targeted delivery of a phosphoinositide 3-kinase γ inhibitor to restore organ function in sepsis through dye-functionalized lipid nanocarriers

The paper demonstrates that dye-functionalized lipid nanocarriers can deliver a PI3Kγ inhibitor to hepatocytes, restoring liver function in sepsis without affecting immune responses.