A new chemoenzymatic semisynthetic approach provides novel insight into the role of phosphorylation beyond exon1 of Huntingtin and reveals N-terminal fragment length-dependent distinct mechanisms of aggregation
Kolla Rajasekhar, Pushparathinam Gopinath, Jonathan Ricci, Andreas Reif, Iman Rostami, Hilal Ahmed Lashuel
This paper investigates the aggregation mechanisms of different N-terminal Htt fragments and introduces a chemoenzymatic method for site-specific phosphorylation beyond Httex1.
Journal of the American Chemical Society · Jun 23, 2021Peer-reviewedNeuroscience