Author

Pushparathinam Gopinath

École Polytechnique Fédérale de LausanneORCID 0000-0002-6577-2357Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 1

Frequent Co-Authors

Hilal Ahmed LashueliD· 2 shared Kolla RajasekhariD· 2 shared Andreas Reif· 1 shared Hilda MirbahaiD· 1 shared Iman RostamiiD· 1 shared Jonathan RicciiD· 1 shared Mahmood Haj‐YahyaiD· 1 shared Marc I. DiamondiD· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 19 mutual co-author links

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2 shared papersNeuroscience

Hilal Ahmed LashuelORCID

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2 papers

Recent·Most cited

NeuroscienceJournal of the American Chemical SocietyPeer-reviewedJun 23, 2021

A new chemoenzymatic semisynthetic approach provides novel insight into the role of phosphorylation beyond exon1 of Huntingtin and reveals N-terminal fragment length-dependent distinct mechanisms of aggregation

Kolla Rajasekhar, Pushparathinam Gopinath, Jonathan Ricci…·Hilal Ahmed Lashuel

This paper investigates the aggregation mechanisms of different N-terminal Htt fragments and introduces a chemoenzymatic method for site-specific phosphorylation beyond Httex1.

16 citations

humanexperimental assay

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NeuroscienceAngewandte Chemie International EditionPeer-reviewedDec 21, 2019

Site-specific hyperphosphorylation of tau inhibits its fibrillization in vitro, blocks its seeding capacity in cells, and disrupts its microtubule binding; Implications for the native state stabilization of tau

Mahmood Haj‐Yahya, Pushparathinam Gopinath, Kolla Rajasekhar…·Hilal Ahmed Lashuel

This study shows that site-specific hyperphosphorylation of tau inhibits its aggregation and microtubule binding, challenging the hyperphosphorylation hypothesis of tau pathology.

105 citationstop 2%

experimental assay

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