Iman Rostami

Differentiated SH-SY5Y Cells Exhibit Neuronal Features but Lack Synaptic Maturity

The paper evaluates the synaptic maturity of SH-SY5Y cells after differentiation and finds they lack functional synapses despite some presynaptic features.

Advancing Human iPSC-Derived Motor Neuron Models Using Glutamatergic Modulators for Synaptic Function Studies

This study improves human iPSC-derived motor neuron synapse formation using optimized differentiation and glutamatergic modulators, resulting in functional and structurally mature neuronal networks.

Visualizing alpha-synuclein and iron deposition in M83 mouse model of Parkinson's disease in vivo

The paper visualizes alpha-synuclein inclusions and iron deposition in M83 mouse models of Parkinson's disease using in vivo imaging and ex vivo validation techniques.

Post-fibrillization nitration of alpha-synuclein abolishes its seeding activity and pathology formation in primary neurons and in vivo

This study shows that nitration of alpha-synuclein after fibrillization reduces its seeding activity and pathology formation in neurons and in vivo.

A novel mutation (E83Q) unlocks the pathogenicity of human alpha-synuclein fibrils and recapitulates its pathological diversity

The paper investigates the effects of the E83Q mutation on alpha-synuclein aggregation and toxicity, finding it accelerates fibrillization and enhances pathological features in neuronal models.

A new chemoenzymatic semisynthetic approach provides novel insight into the role of phosphorylation beyond exon1 of Huntingtin and reveals N-terminal fragment length-dependent distinct mechanisms of aggregation

This paper investigates the aggregation mechanisms of different N-terminal Htt fragments and introduces a chemoenzymatic method for site-specific phosphorylation beyond Httex1.