Kolla Rajasekhar

A new chemoenzymatic semisynthetic approach provides novel insight into the role of phosphorylation beyond exon1 of Huntingtin and reveals N-terminal fragment length-dependent distinct mechanisms of aggregation

This paper investigates the aggregation mechanisms of different N-terminal Htt fragments and introduces a chemoenzymatic method for site-specific phosphorylation beyond Httex1.

Naphthalene monoimide derivative ameliorates amyloid burden and cognitive decline in a transgenic mouse model of Alzheimer's disease

This study identifies TGR63, a naphthalene monoimide derivative, as a promising therapeutic for Alzheimer's disease by reducing amyloid burden and cognitive decline in a mouse model.

Site-specific hyperphosphorylation of tau inhibits its fibrillization in vitro, blocks its seeding capacity in cells, and disrupts its microtubule binding; Implications for the native state stabilization of tau

This study shows that site-specific hyperphosphorylation of tau inhibits its aggregation and microtubule binding, challenging the hyperphosphorylation hypothesis of tau pathology.