Autoantibodies in patients with arrhythmogenic cardiomyopathy activate GSK-3β resulting in a loss of cardiomyocyte cohesion
Soumyata Pathak, Konstanze Stangner, Ellen Kempf, Sina Moztarzadeh, Matthias Hiermaier, Stephanie Wider, M Rauschmayer, Tatjana Williams, Andreas Stengl, Brenda Gerull, Ruth Biller, Sebastian Clauß, Stefan Kääb, Tomo Šarić, Sunil Yeruva, Jens Waschke
This study identifies pathogenic autoantibodies against DSG2 in ACM patients that impair cardiomyocyte cohesion via GSK-3β activation.
Acta Physiologica · May 31, 2026Peer-reviewedCell Biology