Jens Waschke

This study identifies pathogenic autoantibodies against DSG2 in ACM patients that impair cardiomyocyte cohesion via GSK-3β activation.

This study uses STED/AFM to measure E-cadherin binding and mechanical properties in migrating keratinocytes, showing functional E-cadherin remains available for re-engagement during wound healing.

This study shows apremilast improves cardiomyocyte cohesion and reduces arrhythmia in human and murine arrhythmogenic cardiomyopathy models.

This study shows that a DSG2 mutation causing Dsg2 truncation leads to a lethal intestinal barrier defect and a skewed IL17 response in mice, similar to Crohn's disease.