Cell State Chaos Underpins the Evolution of SMARCA4-Deficient Dedifferentiated Endometrial Cancer
Mackenzie Brandon‐Coatham, Julia Avian Vassalakis, Hannah Plummer, Jasleen Kaur, Farzaneh Afzali, Zhihua Xu, Guihua Zhang, Jiahui Liu, Wei Wang, Einav Wajsbrot Renert, Tyler T. Cooper, Alan Dimitriev, Cierra Perron, Andrew Garven, S Abebe, , Lynne-Marie M Postovit
This study shows that SMARCA4 loss in endometrial cancer leads to cell state chaos, not stemness, causing dedifferentiation through epigenomic dysregulation.
bioRxiv · Dec 3, 2025 · PreprintCancer Biology