Author

Amber L. Simpson

Queen's UniversityORCID 0000-0002-4387-8417Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Genetic & Genomic Medicine· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

Andrew GarveniD· 3 shared David Monty BermaniD· 3 shared Lynne-Marie M PostovitiD· 3 shared Alan DimitrieviD· 2 shared Andrew W. CraigiD· 2 shared Charles H. GrahamiD· 2 shared Gane Ka‐Shu WongiD· 2 shared Madhuri KotiiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCancer Biology

Andrew GarvenORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Cancer BiologybioRxivPreprintMay 10, 2026

Failure of Bacillus Calmette-Guerin Therapy in Patients with Bladder Cancer is Characterized by Immune Dysfunction Associated with Activator Protein 1

Andrew Garven, Jean‐François Paré, Alexandra Robins…·Charles H. Graham

This study identifies immune dysfunction linked to AP-1 in BCG non-responders with NMIBC, suggesting pre-existing immunosenescence contributes to early recurrence.

DOI 10.64898/2026.05.06.723215

humanscRNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintDec 3, 2025

Cell State Chaos Underpins the Evolution of SMARCA4-Deficient Dedifferentiated Endometrial Cancer

Mackenzie Brandon‐Coatham, Julia Avian Vassalakis, Hannah Plummer…·Lynne-Marie M Postovit

This study shows that SMARCA4 loss in endometrial cancer leads to cell state chaos, not stemness, causing dedifferentiation through epigenomic dysregulation.

DOI 10.64898/2025.12.01.690470

mousescRNA-seq

𝕏 PostBluesky

ImmunologyCancer ResearchPeer-reviewedApr 29, 2025

Fes-deficient macrophages enhance CD8+ T cell priming and tumour control through increased proinflammatory cytokine production and localization

Brian J. Laight, Danielle Harper, Natasha Dmytryk…·Peter A. Greer

3 citations

mousebulk RNA-seq

𝕏 PostBluesky

Genetic & Genomic MedicinemedRxivPreprintJun 19, 2024

Minimizing biological risk for novel inhibitory drug targets: One knockout is all you need

Alan Dimitriev, Lynne-Marie M Postovit, Amber L. Simpson, Gane Ka‐Shu Wong

The paper shows that analyzing healthcare records and DNA sequences can predict drug effects by treating inhibitory drugs as loss-of-function variants, using data from biobanks like UK Biobank.

DOI 10.1101/2024.06.19.24309116

humanbulk RNA-seq

𝕏 PostBluesky