SorCS2 dynamically interacts with TrkB and GluN2B to control neurotransmission and Huntington's disease progression
Alena Salašová, Niels Sanderhoff Degn, Павельев Михаил Николаевич, Niels Kjærgaard Madsen, Saray López‐Benito, Plinio Cabrera Casarotto, Peter Lund Ovesen, Benedicte Vestergaard, Andreea Cornelia Udrea, Lilian Kisiswa, Lucie Woloszczuková, Islam Mustafa Galal Faress, Sadegh Nabavi, Eero Ċastrén, Juan Carlos Arévalo, , Anders Nykjær
This study shows SorCS2 deficiency worsens Huntington's disease in mice by disrupting BDNF signaling and NMDA receptor function in striatal neurons.
bioRxiv · Nov 3, 2021 · PreprintNeuroscience