Anders Nykjær

This study identifies SorCS2 as a regulator of Wnt signaling homeostasis by controlling Ror2 trafficking and signaling, with implications for neurodevelopment.

This study investigates sortilin's role in retinal homeostasis and injury response, finding it does not prevent neurodegeneration but affects glial activation and neurotrophin dynamics.

This study genetically modifies human pluripotent stem cells to generate lineage-restricted undifferentiated stem cells that efficiently produce mesencephalic dopaminergic neurons for potential clinical applications.

This study shows that SorCS2 is critical for neurovascular coupling in mice through its role in glutamatergic and calcium signaling in astrocytes.

This study identifies SorCS2 as a receptor for progranulin that regulates motor axon outgrowth in zebrafish and mice, with loss-of-function phenotypes observed in both species.

This study shows SorCS2 deficiency worsens Huntington's disease in mice by disrupting BDNF signaling and NMDA receptor function in striatal neurons.

This study identifies SorCS2 as a regulator of EAAT3 trafficking that protects neurons from oxidative stress and epilepsy-induced damage.