Sadegh Nabavi

The paper shows that innate and learned threats in mice use similar circuit mechanisms but differ in how access to these mechanisms is achieved.

This study shows that semaglutide affects behavior and neural oscillations in healthy mice, suggesting potential therapeutic implications beyond metabolic disorders.

This study shows that complex learning abilities can be inherited through epigenetic modifications in the mammalian brain, as offspring of trained rodents exhibit enhanced neuronal excitability and DNA methylation changes.

This paper introduces a dual-color optogenetic system that enables high-frequency neuronal activation with red light and precise suppression with blue light.

This study genetically modifies human pluripotent stem cells to generate lineage-restricted undifferentiated stem cells that efficiently produce mesencephalic dopaminergic neurons for potential clinical applications.

The paper shows that non-Hebbian plasticity can convert transient experiences into lasting memories through synaptic manipulations outside the time of initial learning.

This study demonstrates that self-complementary AAV1 with a strong promoter can enable recombinase-independent anterograde transsynaptic labeling in neural circuits.

The paper shows that the thalamic-basolateral amygdala pathway processes innate and learned threats differently, with distinct neural activity patterns and response mechanisms.

This study shows SorCS2 deficiency worsens Huntington's disease in mice by disrupting BDNF signaling and NMDA receptor function in striatal neurons.

This study shows that PLK2 inhibition reduces soluble nuclear pS129 levels but not aggregated pS129 in synucleinopathy models.

The paper introduces TRACE, a method to label transiently activated synaptic inputs in the brain, validated in four brain regions with known sensory inputs.

The paper demonstrates that alpha-synuclein aggregates spread interneuronally in an organotypic hippocampal slice model, independent of serine 129 phosphorylation.

The paper develops new DREADD agonists and a PET radiotracer for improved neuronal activity manipulation and noninvasive projection mapping in neurotheranostics.