Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder
Laura Jayne Westacott, Trevor Humby, Niels Haan, Sophie A. Brain, Emma‐Louise Bush, Margarita Toneva, Andreea-Ingrid Baloc, Anna L. Moon, Jack Reddaway, Michael John Owen, Jérémy Hall, Timothy R. Hughes, B. Paul Morgan, William Gray, Lawrence S. Wilkinson
This study shows that complement components C3 and C3aR differentially affect innate anxiety and conditioned fear in mice, linking complement pathways to psychiatric disorder risk.
Brain Behavior and Immunity · Sep 17, 2021Peer-reviewedNeuroscience